Rosmarinus Improved Skin Flap Survival Through mTOR Dependent Pathway
نویسندگان
چکیده
منابع مشابه
Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival
BACKGROUND It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. METHODS Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with all...
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The mechanistic target of rapamycin (mTOR) kinase is a conserved regulator of cell growth, proliferation, and survival. In cells, mTOR is the catalytic subunit of two complexes called mTORC1 and mTORC2, which have distinct upstream regulatory signals and downstream substrates. mTORC1 directly senses cellular nutrient availability while indirectly sensing circulating nutrients through growth fac...
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Objective(s): Skin flap necrosis is the most common postoperative side effect in reconstructive surgeries. Glutamine (GLN) has been shown to accelerate wound healing process. The purpose of this study was to evaluate the effects of GLN either in free form or in the dipeptide form along with L- alanyl (Ala-GLN) on random skin flaps survival in rats.Materials and Methods: Dorsal skin flaps with c...
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ژورنال
عنوان ژورنال: Serbian Journal of Dermatology and Venereology
سال: 2018
ISSN: 2406-0631,1821-0902
DOI: 10.2478/sjdv-2018-0016